The world system is different from the godly system (2 Thessalonians 2:7-10). The world says you're saved by works but the Bible says you're saved by grace (Ephesians 2:8-10). The world says there are many ways to Heaven but the Bible says that Jesus is the only Way (John 14:6). The world wants salvation without sanctification but the Bible says that God's grace saves people from their sins (Titus 2:11-14). In short, the whole world is at war with God but Christians are told to preach anyway.
Any true man of God doesn't care about popularity. There's no use getting jealous at the prosperity of the wicked because it doesn't contribute to salvation. Even if the wicked do what they want, the Word of God remains the same. The duty still remains the same whether the world accepts the message of God or not. It's always been preach what the Bible says.